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A Novel Chimeric Antigen Receptor (CAR) - Strategy to Target EGFR<sup>VIII</sup>-Mutated Glioblastoma Cells via Macrophages

2025-11-11

Abstract excerpt

Autologous chimeric antigen receptor (CAR) expressing T-Cells (CAR-T) have been efficiently used in hematological malignancies but their efficacy in solid tumors remain limited. CAR therapies via the use of macrophages, offer a promising avenue due to their unique ability to infiltrate tumors and to initiate phagocytosis. To generate a model of CAR-macrophage for cancer therapy, we have designed a novel CAR monocy...

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Literature Corpus work: 5b20e56d-f210-55e2-8bad-1795050f407a
DOI: 10.20944/preprints202511.0645.v1

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