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Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases

31 Jul 2020

Abstract excerpt

The macrophage is a key cell in the pro- and anti-inflammatory response including that of the inflammatory microenvironment of malignant tumors. Much current drug development in chronic inflammatory diseases and cancer therefore focuses on the macrophage as a target for immunotherapy. However, this strategy is complicated by the pleiotropic phenotype of the macrophage that is highly responsive to its...

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PMID: 32752088
DOI: 10.3390/ijms21155497

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