Article
TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content.
Frontiers in immunology - 1 Jan 2023
Gunalp Sinem, Helvaci Derya Goksu, Oner Aysenur, Bursalı Ahmet, Conforte Alessandra, Güner Hüseyin, Karakülah Gökhan, Szegezdi Eva, Sag Duygu
Abstract excerpt
Background: TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can either induce cell death or activate survival pathways after binding to death receptors (DRs) DR4 or DR5. TRAIL is investigated as a therapeutic agent in clinical trials due to its selective toxicity to transformed cells. Macrophages can be polarized into pro-inflammatory/tumor-fighting M1 macrophages or...
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