Article
Using Clinical Characteristics to Identify Which Patients With Major Depressive Disorder Have a Higher Genetic Load for Three Psychiatric Disorders.
Biological psychiatry - 15 Feb 2017
Verduijn Judith, Milaneschi Yuri, Peyrot Wouter J, Hottenga Jouke Jan, Abdellaoui Abdel, de Geus Eco J C, Smit Johannes H, Breen Gerome, Lewis Cathryn M, Boomsma Dorret I, Beekman Aartjan T F, Penninx Brenda W J H
Abstract excerpt
BACKGROUND: Limited successes of gene finding for major depressive disorder (MDD) may be partly due to phenotypic heterogeneity. We tested whether the genetic load for MDD, bipolar disorder, and schizophrenia (SCZ) is increased in phenotypically more homogenous MDD patients identified by specific clinical characteristics. METHODS: Patients (n = 1539) with a DSM-IV MDD diagnosis and control subjects (n = 1792)...
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