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Article

Polygenic dissection of major depression clinical heterogeneity.

Molecular psychiatry - 1 Apr 2016

Milaneschi Y, Lamers F, Peyrot W J, Abdellaoui A, Willemsen G, Hottenga J-J, Jansen R, Mbarek H, Dehghan A, Lu C, Boomsma D I, Penninx B W J H

Abstract excerpt

The molecular mechanisms underlying major depressive disorder (MDD) are largely unknown. Limited success of previous genetics studies may be attributable to heterogeneity of MDD, aggregating biologically different subtypes. We examined the polygenic features of MDD and two common clinical subtypes (typical and atypical) defined by symptom profiles in a large sample of adults with established diagnoses. Data were...

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Identifiers

PMID: 26122587
DOI: 10.1038/mp.2015.86
PMCID: PMC5546325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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