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Article

Exploring the genetic heterogeneity in major depression across diagnostic criteria.

Molecular psychiatry - 1 Dec 2021

Jermy Bradley S, Glanville Kylie P, Coleman Jonathan R I, Lewis Cathryn M, Vassos Evangelos

Abstract excerpt

Major depressive disorder (MDD) is defined differently across genetic research studies and this may be a key source of heterogeneity. While previous literature highlights differences between minimal and strict phenotypes, the components contributing to this heterogeneity have not been identified. Using the cardinal symptoms (depressed mood/anhedonia) as a baseline, we build MDD phenotypes using five...

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Identifiers

PMID: 34290369
DOI: 10.1038/s41380-021-01231-w
PMCID: PMC8872976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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