Article
Identifying genetic differences between bipolar disorder and major depression through multiple genome-wide association analyses.
The British journal of psychiatry : the journal of mental science - 1 Feb 2025
Panagiotaropoulou Georgia, Hellberg Kajsa-Lotta Georgii, Coleman Jonathan R I, Seok Darsol, Kalman Janos, Mitchell Philip B, Schofield Peter R, Forstner Andreas J, Bauer Michael, Scott Laura J, Pato Carlos N, Pato Michele T, Li Qingqin S, Kirov George, Landén Mikael, Jonsson Lina, Müller-Myhsok Bertram, Smoller Jordan W, Binder Elisabeth B, Brückl Tanja M, Czamara Darina, Van der Auwera Sandra, Grabe Hans J, Homuth Georg, Schmidt Carsten O, Potash James B, DePaulo J Raymond, Goes Fernando S, MacKinnon Dean F, Mondimore Francis M, Weissman Myrna M, Shi Jianxin, Frye Mark A, Biernacka Joanna M, Reif Andreas, Witt Stephanie H, Kahn René R, Boks Marco M, Owen Michael J, Gordon-Smith Katherine, Mitchell Brittany L, Martin Nicholas G, Medland Sarah E, Jones Lisa, Knowles James A, Levinson Douglas F, O'Donovan Michael C, Lewis Cathryn M, Breen Gerome, Werge Thomas, Schork Andrew J, Ophoff Roel A, Ripke Stephan, Olde Loohuis Loes
Abstract excerpt
BACKGROUND: Accurate diagnosis of bipolar disorder (BPD) is difficult in clinical practice, with an average delay between symptom onset and diagnosis of about 7 years. A depressive episode often precedes the first manic episode, making it difficult to distinguish BPD from unipolar major depressive disorder (MDD). AIMS: We use genome-wide association analyses (GWAS) to identify differential genetic factors and to...
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