Article
Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.
Biological psychiatry - 15 Feb 2017
Power Robert A, Tansey Katherine E, Buttenschøn Henriette Nørmølle, Cohen-Woods Sarah, Bigdeli Tim, Hall Lynsey S, Kutalik Zoltán, Lee S Hong, Ripke Stephan, Steinberg Stacy, Teumer Alexander, Viktorin Alexander, Wray Naomi R, Arolt Volker, Baune Bernard T, Boomsma Dorret I, Børglum Anders D, Byrne Enda M, Castelao Enrique, Craddock Nick, Craig Ian W, Dannlowski Udo, Deary Ian J, Degenhardt Franziska, Forstner Andreas J, Gordon Scott D, Grabe Hans J, Grove Jakob, Hamilton Steven P, Hayward Caroline, Heath Andrew C, Hocking Lynne J, Homuth Georg, Hottenga Jouke J, Kloiber Stefan, Krogh Jesper, Landén Mikael, Lang Maren, Levinson Douglas F, Lichtenstein Paul, Lucae Susanne, MacIntyre Donald J, Madden Pamela, Magnusson Patrik K E, Martin Nicholas G, McIntosh Andrew M, Middeldorp Christel M, Milaneschi Yuri, Montgomery Grant W, Mors Ole, Müller-Myhsok Bertram, Nyholt Dale R, Oskarsson Hogni, Owen Michael J, Padmanabhan Sandosh, Penninx Brenda W J H, Pergadia Michele L, Porteous David J, Potash James B, Preisig Martin, Rivera Margarita, Shi Jianxin, Shyn Stanley I, Sigurdsson Engilbert, Smit Johannes H, Smith Blair H, Stefansson Hreinn, Stefansson Kari, Strohmaier Jana, Sullivan Patrick F, Thomson Pippa, Thorgeirsson Thorgeir E, Van der Auwera Sandra, Weissman Myrna M, Breen Gerome, Lewis Cathryn M
Abstract excerpt
BACKGROUND: Major depressive disorder (MDD) is a disabling mood disorder, and despite a known heritable component, a large meta-analysis of genome-wide association studies revealed no replicable genetic risk variants. Given prior evidence of heterogeneity by age at onset in MDD, we tested whether genome-wide significant risk variants for MDD could be identified in cases subdivided by age at onset. METHODS:...
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