Article
Genetics of major depressive disorder in a homogeneous population with uniform phenotyping.
Molecular psychiatry - 1 Oct 2026
Huider Floris, Milaneschi Yuri, Pool René, Maciel Bernardo de A P C, Gordon Scott D, Han Jihee, Rietman M Liset, Kok Almar A L, Galesloot Tessel E, Mitchell Brittany L, 't Hart Leen M, Rutters Femke, Blom Marieke T, Rhebergen Didi, Visser Marjolein, Brouwer Ingeborg A, Feskens Edith, Hartman Catharina A, Oldehinkel Albertine J, Bot Mariska, de Geus Eco J C, Kiemeney Lambertus A, Huisman Martijn, Picavet H Susan J, Verschuren W M Monique, Martin Nicholas G, Dolan Conor V, van Loo Hanna M, Penninx Brenda W J H, Hottenga Jouke-Jan, Boomsma Dorret I
Abstract excerpt
Harmonized phenotyping and diverse population-specific studies are crucial for advancing gene discovery in psychiatric genetics. We conducted a genome-wide association (GWAS) mega-analysis of DSM-defined lifetime major depressive disorder (MDD) in 64 941 participants (25.7% cases) from the Dutch BIObanks Netherlands Internet Collaboration (BIONIC) consortium. Liability-scale SNP-based heritability was 12.0%...
Read the complete abstract on PubMedTopics
- Humans
- Major Depressive Disorder
- Genome-Wide Association Study
