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Article

An experimental evaluation of drug‐induced mutational meltdown as an antiviral treatment strategy

27 Aug 2016

Abstract excerpt

The rapid evolution of drug resistance remains a critical public health concern. The treatment of influenza A virus (IAV) has proven particularly challenging, due to the ability of the virus to develop resistance against current antivirals and vaccines. Here, we evaluate a novel antiviral drug therapy, favipiravir, for which the mechanism of action in IAV involves an interaction with the viral RNA-dependent RNA...

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PMID: 27566611
DOI: 10.1111/evo.13041

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