Article

Within-host virus evolution during the extended treatment of RSV infection with mutagenic drugs

2022-09-18

Abstract excerpt

Antiviral drugs causing viral mutagenesis have shown value against a broad range of RNA viruses causing respiratory illnesses. While drug-induced accumulation of mutations generally decreases viral fitness, the potential for mutagenesis to generate escape variants is unknown and concerns have been raised about adaptive evolution promoting drug-resistance. We report prolonged treatment of a life-threatening RSV inf...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0a9190c-032a-51fd-bcda-6ca093e2f098
DOI: 10.1101/2022.09.02.22279474

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Within-host virus evolution during the extended treatment of RSV infection with mutagenic drugsDOI 10.1101/2022.09.02.22279474Read

Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infectionSemantic proximity Read

Concepts of RNA virus evolution for the design of better antiviral countermeasures.Semantic proximity Read

Favipiravir induces HuNoV viral mutagenesis and infectivity loss with clinical improvement in immunocompromised patientsSemantic proximity Read

Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infectionSemantic proximity Read

Implications of high RNA virus mutation rates: lethal mutagenesis and the antiviral drug ribavirin.Semantic proximity Read

Harnessing host–virus evolution in antiviral therapy and immunotherapySemantic proximity Read

SARS-CoV-2 Error Catastrophe Under Molnupiravir: Mutagenic Enhancement Enables Viral Persistence with Impaired Fitness.Semantic proximity Read

An experimental evaluation of drug‐induced mutational meltdown as an antiviral treatment strategySemantic proximity Read

Within-host whole-genome deep sequencing and diversity analysis of human respiratory syncytial virus infection reveals dynamics of genomic diversity in the absence and presence of immune pressure.Semantic proximity Read

Mutagenic Effects of Ribavirin on Hepatitis E Virus-Viral Extinction versus Selection of Fitness-Enhancing Mutations.Semantic proximity Read

Future prospects for the treatment of rapidly evolving viral pathogens: insights from evolutionary biology.Semantic proximity Read

Ribavirin and lethal mutagenesis of poliovirus: molecular mechanisms, resistance and biological implications.Semantic proximity Read