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Article

Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro.

Journal of virology - 1 Jan 2014

Renzette Nicholas, Caffrey Daniel R, Zeldovich Konstantin B, Liu Ping, Gallagher Glen R, Aiello Daniel, Porter Alyssa J, Kurt-Jones Evelyn A, Bolon Daniel N, Poh Yu-Ping, Jensen Jeffrey D, Schiffer Celia A, Kowalik Timothy F, Finberg Robert W, Wang Jennifer P

Abstract excerpt

Influenza A virus (IAV) is a major cause of morbidity and mortality throughout the world. Current antiviral therapies include oseltamivir, a neuraminidase inhibitor that prevents the release of nascent viral particles from infected cells. However, the IAV genome can evolve rapidly, and oseltamivir resistance mutations have been detected in numerous clinical samples. Using an in vitro evolution platform and...

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Identifiers

PMID: 24155392
DOI: 10.1128/JVI.01067-13
PMCID: PMC3911755

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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