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Article

The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution

1 Jul 2017

Abstract excerpt

Influenza virus inflicts a heavy death toll annually and resistance to existing antiviral drugs has generated interest in the development of agents with novel mechanisms of action. Favipiravir is an antiviral drug that acts by increasing the genome-wide mutation rate of influenza A virus (IAV). Potential synergistic benefits of combining oseltamivir and favipiravir have been demonstrated in animal models of...

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PMID: 28854600
DOI: 10.1093/gbe/evx138

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