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Article

Inferring the distribution of fitness effects in patient-sampled and experimental virus populations: two case studies.

Heredity - 1 Feb 2022

Morales-Arce Ana Y, Johri Parul, Jensen Jeffrey D

Abstract excerpt

We here propose an analysis pipeline for inferring the distribution of fitness effects (DFE) from either patient-sampled or experimentally-evolved viral populations, that explicitly accounts for non-Wright-Fisher and non-equilibrium population dynamics inherent to pathogens. We examine the performance of this approach via extensive power and performance analyses, and highlight two illustrative applications - one...

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Identifiers

PMID: 34987185
DOI: 10.1038/s41437-021-00493-y
PMCID: PMC8728706

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