Modelling the emergence of influenza drug resistance: The roles of surface proteins, the immune response and antiviral mechanisms.

Abstract excerpt

The emergence of influenza drug resistance has become of particular interest as current planning for an influenza pandemic involves using massive amounts of antiviral drugs. We use semi-stochastic simulations to examine the emergence of drug resistant mutants during the course of a single infection within a patient in the presence and absence of antiviral therapy. We specifically examine three factors and their...

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