Article
Influenza virus drug resistance: a time-sampled population genetics perspective.
PLoS genetics - 1 Feb 2014
Foll Matthieu, Poh Yu-Ping, Renzette Nicholas, Ferrer-Admetlla Anna, Bank Claudia, Shim Hyunjin, Malaspinas Anna-Sapfo, Ewing Gregory, Liu Ping, Wegmann Daniel, Caffrey Daniel R, Zeldovich Konstantin B, Bolon Daniel N, Wang Jennifer P, Kowalik Timothy F, Schiffer Celia A, Finberg Robert W, Jensen Jeffrey D
Abstract excerpt
The challenge of distinguishing genetic drift from selection remains a central focus of population genetics. Time-sampled data may provide a powerful tool for distinguishing these processes, and we here propose approximate Bayesian, maximum likelihood, and analytical methods for the inference of demography and selection from time course data. Utilizing these novel statistical and computational tools, we evaluate...
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