Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary Dynamics of Accelerated Antiviral Resistance Development in Hypermutator Herpesvirus.

Molecular biology and evolution - 3 Jul 2024

Höfler Thomas, Nascimento Mariana Mara, Zeitlow Michaela, Kim Ji Yoon, Trimpert Jakob

Abstract excerpt

Antiviral therapy is constantly challenged by the emergence of resistant pathogens. At the same time, experimental approaches to understand and predict resistance are limited by long periods required for evolutionary processes. Here, we present a herpes simplex virus 1 mutant with impaired proofreading capacity and consequently elevated mutation rates. Comparing this hypermutator to parental wild type virus, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Biological Evolution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to Evolution, Molecular

Share to Herpesvirus 1, Human

Share to Mutation

Share to Mutation Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 38879872
DOI: 10.1093/molbev/msae119
PMCID: PMC11226790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary Dynamics of Accelerated Antiviral Resistance Development in Hypermutator Herpesvirus.PMID 38879872Read ↗

Antiviral drug resistance as an adaptive processSemantic proximity Read ↗

More efficacious drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1Semantic proximity Read ↗

More effective drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1.Semantic proximity Read ↗

Mode of selection and experimental evolution of antiviral drugs resistance in vesicular stomatitis virus.Semantic proximity Read ↗

Imposed mutational meltdown as an antiviral strategy.Semantic proximity Read ↗

Evolutionary pathways of transmitted drug-resistant HIV-1Semantic proximity Read ↗

Low frequency variants can predetermine antiviral drug resistance development in herpes simplex virus type 1.Semantic proximity Read ↗

A new paradigm in viral resistance.Semantic proximity Read ↗

Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses?Semantic proximity Read ↗

HIV-1 mutagenesis during antiretroviral therapy: implications for successful drug treatment.Semantic proximity Read ↗

Future prospects for the treatment of rapidly evolving viral pathogens: insights from evolutionary biology.Semantic proximity Read ↗

An experimental evaluation of drug‐induced mutational meltdown as an antiviral treatment strategySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.