Article
Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage.
Biochimica et biophysica acta - 1 Nov 2016
Sakamaki Kazuhiro, Ishii Takahiro M, Sakata Toshiya, Takemoto Kiwamu, Takagi Chiyo, Takeuchi Ayako, Morishita Ryo, Takahashi Hirotaka, Nozawa Akira, Shinoda Hajime, Chiba Kumiko, Sugimoto Haruyo, Saito Akiko, Tamate Shuhei, Satou Yutaka, Jung Sang-Kee, Matsuoka Satoshi, Koyamada Koji, Sawasaki Tatsuya, Nagai Takeharu, Ueno Naoto
Abstract excerpt
Activation of caspases is crucial for the execution of apoptosis. Although the caspase cascade associated with activation of the initiator caspase-8 (CASP8) has been investigated in molecular and biochemical detail, the physiological role of CASP8 is not fully understood. Here, we identified a two-pore domain potassium channel, tandem-pore domain halothane-inhibited K+ channel 1 (THIK-1), as a novel CASP8...
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