Article
Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosis.
Cell death and differentiation - 1 Aug 2002
Schwab B L, Guerini D, Didszun C, Bano D, Ferrando-May E, Fava E, Tam J, Xu D, Xanthoudakis S, Nicholson D W, Carafoli E, Nicotera P
Abstract excerpt
Neuronal death, which follows ischemic injury or is triggered by excitotoxins, can occur by both apoptosis and necrosis. Caspases, which are not directly required for necrotic cell death, are central mediators of the apoptotic program. Here we demonstrate that caspases cleave and inactivate the plasma membrane Ca(2+) pump (PMCA) in neurons and non-neuronal cells undergoing apoptosis. PMCA cleavage impairs...
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