Article
Necroptosis and apoptosis contribute to cisplatin and aminoglycoside ototoxicity
2018-05-26
Abstract excerpt
Ototoxic side effects of cisplatin and aminoglycosides have been extensively studied, but no therapy is available to date. Sensory hair cells, upon exposure to cisplatin or aminoglycosides, undergo apoptotic and necrotic cell death. Blocking these cell death pathways has therapeutic potential in theory, but incomplete protection and lack of therapeutic targets in the case of necrosis, has hampered the development...
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Identifiers and source
- Literature Corpus work
- 0e5a132a-5e36-581c-85dd-280c4fa93739
- DOI
- 10.1101/332031