Article

Doxorubicin induces caspase-mediated proteolysis of K <sub>V</sub> 7.1

2018-02-03

Abstract excerpt

The voltage-gated potassium channel K v 7.1 (KCNQ1) co-assembles with KCNE1 to generate the cardiac potassium current I Ks . Gain- and loss-of-function mutations in KCNQ1 are associated with atrial fibrillation and long-QT (LQT) syndrome, respectively, highlighting the importance of modulating I KS activity for proper cardiac function. On a post-translational level, I KS can be regulated by phosphorylation, u...

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Literature Corpus work: 0358df1a-7a11-5be5-bd40-718dd85e5099
DOI: 10.1101/259242

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