Article
Perturbation of intracellular K(+) homeostasis with valinomycin promotes cell death by mitochondrial swelling and autophagic processes.
Apoptosis : an international journal on programmed cell death - 1 Nov 2011
Klein Barbara, Wörndl Katrin, Lütz-Meindl Ursula, Kerschbaum Hubert H
Abstract excerpt
Perturbation of cellular K(+) homeostasis is a common motif in apoptosis but it is unknown whether a decrease in intracellular K(+) alone is sufficient to replicate apoptotic hallmarks. We investigated, which mode of cell death is induced by decreasing the intracellular K(+) concentration using valinomycin, a highly K(+)-selective ionophore. Valinomycin treatment induced mitochondrial swelling and minor nuclear...
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