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Article

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis.

The Journal of cell biology - 7 Jul 2003

Zong Wei-Xing, Li Chi, Hatzivassiliou Georgia, Lindsten Tullia, Yu Qian-Chun, Yuan Junying, Thompson Craig B

Abstract excerpt

Bax and Bak play a redundant but essential role in apoptosis initiated by the mitochondrial release of apoptogenic factors. In addition to their presence at the mitochondrial outer membrane, Bax and Bak can also localize to the ER. Agents that initiate ER stress responses can induce conformational changes and oligomerization of Bax on the ER as well as on mitochondria. In wild-type cells, this is associated with...

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Identifiers

PMID: 12847083
DOI: 10.1083/jcb.200302084
PMCID: PMC2172724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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