Article
The 29.5 kb APOBEC3B Deletion Polymorphism Is Not Associated with Clinical Outcome of Breast Cancer.
PloS one - 1 Jan 2016
Liu Jingjing, Sieuwerts Anieta M, Look Maxime P, van der Vlugt-Daane Michelle, Meijer-van Gelder Marion E, Foekens John A, Hollestelle Antoinette, Martens John W M
Abstract excerpt
Increased APOBEC3B mRNA levels are associated with a hypermutator phenotype and poor prognosis in ER-positive breast cancer patients. In addition, a 29.5 kb deletion polymorphism of APOBEC3B, resulting in an APOBEC3A-B hybrid transcript, has been associated with an increased breast cancer risk and the hypermutator phenotype. Here we evaluated whether the APOBEC3B deletion polymorphism also associates with...
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