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APOBEC3A/B deletion polymorphism and cancer risk.

Carcinogenesis - 9 Feb 2018

Gansmo Liv B, Romundstad Paal, Hveem Kristian, Vatten Lars, Nik-Zainal Serena, Lønning Per Eystein, Knappskog Stian

Abstract excerpt

Activity of the apolipoprotein B mRNA editing enzyme, catalytic-polypeptide-like (APOBEC) enzymes has been linked to specific mutational processes in human cancer genomes. A germline APOBEC3A/B deletion polymorphism is associated with APOBEC-dependent mutational signatures, and the deletion allele has been reported to confer an elevated risk of some cancers in Asian populations, while the results in European...

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Identifiers

PMID: 29140415
DOI: 10.1093/carcin/bgx131
PMCID: PMC5862322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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