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Identifying germline APOBEC3B deletion and immune phenotype in Korean patients with operable breast cancer.

Breast cancer research and treatment - 1 Oct 2020

Kim Se Hyun, Ahn Soomin, Suh Koung Jin, Kim Yu Jung, Park So Yeon, Kang Eunyoung, Kim Eun-Kyu, Kim In Ah, Chae Sumin, Choi Murim, Kim Jee Hyun

Abstract excerpt

BACKGROUND: Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3B (APOBEC3B) is implicated in anti-viral immune response and cancer mutagenesis. Germline APOBEC3B deletion is associated with increased susceptibility to breast cancer. We aimed to evaluate the association between germline APOBEC3B deletion and clinical phenotypes of breast cancer in Korean patients with operable breast cancer....

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PMID: 32715441
DOI: 10.1007/s10549-020-05811-2

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