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The APOBEC3B c.783delG Truncating Mutation Is Not Associated with an Increased Risk of Breast Cancer in the Polish Population.

Genes - 24 Jun 2023

Gliniewicz Katarzyna, Kluźniak Wojciech, Wokołorczyk Dominika, Huzarski Tomasz, Stempa Klaudia, Rudnicka Helena, Jakubowska Anna, Szwiec Marek, Jarkiewicz-Tretyn Joanna, Naczk Mariusz, Kluz Tomasz, Dębniak Tadeusz, Gronwald Jacek, Lubiński Jan, Narod Steven A, Akbari Mohammad R, Cybulski Cezary

Abstract excerpt

The APOBEC3B gene belongs to a cluster of DNA-editing enzymes on chromosome 22 and encodes an activation-induced cytidine deaminase. A large deletion of APOBEC3B was associated with increased breast cancer risk, but the evidence is inconclusive. To investigate whether or not APOBEC3B is a breast cancer susceptibility gene, we sequenced this gene in 617 Polish patients with hereditary breast cancer. We detected a...

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Identifiers

PMID: 37510234
DOI: 10.3390/genes14071329
PMCID: PMC10379723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The APOBEC3B c.783delG Truncating Mutation Is Not Associated with an Increased Risk of Breast Cancer in the Polish Population.PMID 37510234Read ↗

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