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Article

Impact of the APOBEC3A/B deletion polymorphism on risk of ovarian cancer.

Scientific reports - 6 Dec 2021

Gansmo Liv B, Sofiyeva Nigar, Bjørnslett Merete, Romundstad Pål, Hveem Kristian, Vatten Lars, Dørum Anne, Lønning Per E, Knappskog Stian

Abstract excerpt

A germline 29.5-kb deletion variant removes the 3' end of the APOBEC3A gene and a large part of APOBEC3B, creating a hybrid gene that has been linked to increased APOBEC3 activity and DNA damage in human cancers. We genotyped the APOBEC3A/B deletion in hospital-based samples of 1398 Norwegian epithelial ovarian cancer patients without detected BRCA1/2 germline mutations and compared to 1,918 healthy female...

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Identifiers

PMID: 34873230
DOI: 10.1038/s41598-021-02820-z
PMCID: PMC8648731

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