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Article

Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment.

Journal of affective disorders - 1 Dec 2007

Papiol Sergi, Arias Bárbara, Gastó Cristóbal, Gutiérrez Blanca, Catalán Rosa, Fañanás Lourdes

Abstract excerpt

BACKGROUND: Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been observed in major depression. Normalization of HPA axis has been suggested to play a role in the mechanisms of action of antidepressants. Our aim was to investigate the influence of genetic variants in CRHR1, CRHR2, CRH-BP and FKBP5 genes on both the vulnerability for depression and the response to antidepressant treatment....

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Source

Identifiers

PMID: 17467808
DOI: 10.1016/j.jad.2007.02.017

Genes

CRHR1
CRHR2
CRH
FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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