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Article

Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.

Oncotarget - 20 Sept 2016

Greenwood Erin, Maisel Sabrina, Ebertz David, Russ Atlantis, Pandey Ritu, Schroeder Joyce

Abstract excerpt

We have previously demonstrated that Llgl1 loss results in a gain of mesenchymal phenotypes and a loss of apicobasal and planar polarity. We now demonstrate that these changes represent a fundamental shift in cellular phenotype. Llgl1 regulates the expression of multiple cell identity markers, including CD44, CD49f, and CD24, and the nuclear translocation of TAZ and Slug. Cells lacking Llgl1 form mammospheres,...

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Identifiers

PMID: 27542214
DOI: 10.18632/oncotarget.11320
PMCID: PMC5308616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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