Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment.

Nature communications - 16 Dec 2016

Song Ki-Hoon, Park Mi So, Nandu Tulip S, Gadad Shrikanth, Kim Sang-Cheol, Kim Mi-Young

Abstract excerpt

Some polypeptide N-acetyl-galactosaminyltransferases (GALNTs) are associated with cancer, but their function in organ-specific metastasis remains unclear. Here, we report that GALNT14 promotes breast cancer metastasis to the lung by enhancing the initiation of metastatic colonies as well as their subsequent growth into overt metastases. Our results suggest that GALNT14 augments the self-renewal properties of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diamines
Share to Dioxoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to N-Acetylgalactosaminyltransferases

Share to Neoplasms, Experimental

Share to Polypeptide N-acetylgalactosaminyltransferase

Share to Quinolines

Share to Receptors, Transforming Growth Factor beta

Share to Thiazoles

Source

Open in PubMed Open full text

Identifiers

PMID: 27982029
DOI: 10.1038/ncomms13796
PMCID: PMC5171903

Genes

GALNT14
JUN
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment.PMID 27982029Read ↗

Novel transplantable mouse cell line model recapitulates invasive lobular breast carcinoma (ILC) phenotype and immune microenvironmentSemantic proximity Read ↗

CXCR4+ mammary gland macrophageal niche promotes tumor initiating cell activity and immune suppression during tumorigenesisSemantic proximity Read ↗

A Novel Lung Metastasis Signature Links Wnt Signaling with Cancer Cell Self-Renewal and Epithelial-Mesenchymal Transition in Basal-like Breast CancerSemantic proximity Read ↗

c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion.Semantic proximity Read ↗

A Developmental Lectin-Glycan Program Enables Early Breast Cancer Dissemination and Metastatic OnsetSemantic proximity Read ↗

Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivoSemantic proximity Read ↗

LGR4 modulates breast cancer initiation, metastasis, and cancer stem cellsSemantic proximity Read ↗

LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cellsSemantic proximity Read ↗

Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast CancerSemantic proximity Read ↗

LIN28B enhanced tumorigenesis in an autochthonous KRASG12V-driven lung carcinoma mouse model.Semantic proximity Read ↗

SPDEF enhances cancer stem cell-like properties and tumorigenesis through directly promoting GALNT7 transcription in luminal breast cancerSemantic proximity Read ↗

Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.