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Article

Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.

Cancer research - 15 May 2015

Zhang Shubing, Chung Wen-Cheng, Wu Guanming, Egan Sean E, Miele Lucio, Xu Keli

Abstract excerpt

Claudin-low breast cancer (CLBC) is a poor prognosis disease biologically characterized by stemness and mesenchymal features. These tumors disproportionately affect younger patients and women with African ancestry, causing significant morbidity and mortality, and no effective targeted therapy exists at present. CLBC is thought to originate from mammary stem cells, but little is known on how or why these tumors...

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Source

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Identifiers

PMID: 25808869
DOI: 10.1158/0008-5472.CAN-14-3303
PMCID: PMC4433600

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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