Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization.

The Journal of clinical investigation - 1 Oct 2014

Magrini Elena, Villa Alessandra, Angiolini Francesca, Doni Andrea, Mazzarol Giovanni, Rudini Noemi, Maddaluno Luigi, Komuta Mina, Topal Baki, Prenen Hans, Schachner Melitta, Confalonieri Stefano, Dejana Elisabetta, Bianchi Fabrizio, Mazzone Massimiliano, Cavallaro Ugo

Abstract excerpt

While tumor blood vessels share many characteristics with normal vasculature, they also exhibit morphological and functional aberrancies. For example, the neural adhesion molecule L1, which mediates neurite outgrowth, fasciculation, and pathfinding, is expressed on tumor vasculature. Here, using an orthotopic mouse model of pancreatic carcinoma, we evaluated L1 functionality in cancer vessels. Tumor-bearing mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Vessels
Share to Capillary Permeability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemangioma

Share to Neovascularization, Pathologic

Share to Neural Cell Adhesion Molecule L1

Share to Permeability

Share to Receptor, TIE-2

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 25157817
DOI: 10.1172/JCI70683
PMCID: PMC4191010

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization.PMID 25157817Read ↗

Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions.Semantic proximity Read ↗

LRG1 promotes angiogenesis by modulating endothelial TGF-β signallingSemantic proximity Read ↗

ALK1 signaling regulates early postnatal lymphatic vessel developmentSemantic proximity Read ↗

Immunoregulatory subtype of dermal lymphatic endothelial cells at capillary terminals drives lymphatic malformationsSemantic proximity Read ↗

Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review)Semantic proximity Read ↗

MFG-E8/Lactadherin Promotes Tumor Growth in an Angiogenesis-Dependent Transgenic Mouse Model of Multistage CarcinogenesisSemantic proximity Read ↗

Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodelingSemantic proximity Read ↗

Tumor angiogenesis: causes, consequences, challenges and opportunitiesSemantic proximity Read ↗

Primary tumor–derived systemic nANGPTL4 inhibits metastasisSemantic proximity Read ↗

Deciphering the Origin and Plasticity of Circulating Endothelial Cells: A Model for Systemic Angiogenesis Programs in Health and DiseaseSemantic proximity Read ↗

Endothelial cell malignancies: new insights from the laboratory and clinicSemantic proximity Read ↗

Integrin β1 is an essential factor in vasculogenic mimicry of human cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.