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Targeting Met and Notch in the<i>Lfng</i>-deficient,<i>Met</i>-amplified triple-negative breast cancer

20 Feb 2014

Abstract excerpt

Triple negative breast cancer (TNBC) accounts for 15-20% of breast carcinomas and represents one of the most aggressive forms of this disease. Basal and claudin-low are the two main molecular subtypes among TNBCs. We previously reported that deletion of Lfng in mouse mammary gland caused deregulated Notch activation and induced basal-like and claudin-low tumors with co-selection for Met amplification. In human...

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PMID: 24556651
DOI: 10.4161/cbt.28180

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