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Article

Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

1 May 2009

Abstract excerpt

Lrig1 is a marker of human interfollicular epidermal stem cells and helps maintain stem cell quiescence. We show that, in mouse epidermis, Lrig1 defines the hair follicle junctional zone adjacent to the sebaceous glands and infundibulum. Lrig1 is a Myc target gene; loss of Lrig1 increases the proliferative capacity of stem cells in culture and results in epidermal hyperproliferation in vivo. Lrig1-expressing...

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PMID: 19427292
DOI: 10.1016/j.stem.2009.04.014

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