Article

Tumour-derived LAMA5 is critical for tumour initiation and controls progression and phenotype in luminal breast cancer

2024-12-26

Abstract excerpt

<h4>ABSTRACT</h4> Basement membrane (BM) supports and regulates the structural integrity, function and differentiation of epithelial tissues and protects against stromal invasion of breast cancer cells. Here we show that LAMA5, a central BM component, is critical for luminal mammary tumour initiation, and controls tumor progression and phenotype development. LAMA5 is overexpressed in both human and mouse luminal...

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Literature Corpus work: a16ba3a2-9c95-5e79-8fe1-6cd8f8106302
DOI: 10.1101/2024.12.26.630367

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