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LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells

21 Dec 2017

Abstract excerpt

The fourth member of the leucine-rich repeat-containing GPCR family (LGR4, frequently referred to as GPR48) and its cognate ligands, R-spondins (RSPOs) play crucial roles in the development of multiple organs as well as the survival of adult stem cells by activation of canonical Wnt signaling. Wnt/β-catenin signaling acts to regulate breast cancer; however, the molecular mechanisms determining its spatiotemporal...

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PMID: 29269400
DOI: 10.1096/fj.201700897r

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