Article
Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.
Nature cell biology - 1 Dec 2016
Blaas Leander, Pucci Fabio, Messal Hendrik A, Andersson Agneta B, Josue Ruiz E, Gerling Marco, Douagi Iyadh, Spencer-Dene Bradley, Musch Alexandra, Mitter Richard, Bhaw Leena, Stone Richard, Bornhorst Dorothee, Sesay Abdul K, Jonkers Jos, Stamp Gordon, Malanchi Ilaria, Toftgård Rune, Behrens Axel
Abstract excerpt
The mammary gland is composed of a complex cellular hierarchy with unusual postnatal plasticity. The identities of stem/progenitor cell populations, as well as tumour-initiating cells that give rise to breast cancer, are incompletely understood. Here we show that Lgr6 marks rare populations of cells in both basal and luminal mammary gland compartments in mice. Lineage tracing analysis showed that Lgr6+ cells are...
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