Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro.

Drug design, development and therapy - 1 Jan 2017

Fang Ping, Zheng Xiang, He Jiayang, Ge Honglei, Tang Pengfei, Cai Jianping, Hu Guoxin

Abstract excerpt

BACKGROUND: Cytochrome P450 2D6 (CYP2D6), a member of the CYP450 enzyme super family, is a polymorphic enzyme that metabolizes ~25% of therapeutic drugs. CYP2D6 exhibits significant genetic polymorphisms which might cause adverse effects and therapeutic failures of some drugs. OBJECTIVE: The purpose of this study was to evaluate the catalytic activities of 22 novel CYP2D6 alleles (CYP2D6*87, *88, *89, *90, *91,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Antineoplastic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2D6

Share to Gefitinib

Share to Genetic Variation

Share to Quinazolines

Source

Open in PubMed Open full text

Identifiers

PMID: 28461741
DOI: 10.2147/DDDT.S133814
PMCID: PMC5407444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro.PMID 28461741Read ↗

Profile of the inhibitory effects of gefitinib on CYP2D6 variants in vitro.Semantic proximity Read ↗

Comparison of cytochrome P450 2D6 and variants in terms of drug oxidation rates and substrate inhibition.Semantic proximity Read ↗

Functional characterization of wild-type and 49 CYP2D6 allelic variants for N-desmethyltamoxifen 4-hydroxylation activity.Semantic proximity Read ↗

Functional characterization of 22 novel CYP2D6 variants for the metabolism of Tamoxifen.Semantic proximity Read ↗

Assessment of 25 CYP2D6 alleles found in the Chinese population on propafenone metabolism in vitro.Semantic proximity Read ↗

A Review of the Important Role of CYP2D6 in Pharmacogenomics.Semantic proximity Read ↗

Effects of polymorphisms in CYP2D6 and ABC transporters and side effects induced by gefitinib on the pharmacokinetics of the gefitinib metabolite, O-desmethyl gefitinib.Semantic proximity Read ↗

Effects of 22 novel CYP2D6 variants found in Chinese population on the metabolism of dapoxetine.Semantic proximity Read ↗

Identification and drug metabolic activity evaluation of 12 CYP2D6 allelic variants newly detected in the Chinese population.Semantic proximity Read ↗

In vitro functional assessment of 22 newly identified CYP2D6 allelic variants in the Chinese population.Semantic proximity Read ↗

Functional characterization of 26 CYP2B6 allelic variants (CYP2B6.2-CYP2B6.28, except CYP2B6.22).Semantic proximity Read ↗

Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.