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Effect of 22 CYP2D6 variants found in the Chinese population on tolterodine metabolism in vitro.

Chemico-biological interactions - 25 Feb 2017

Wang Hao, Dai Da-Peng, Sun Peng, Xu Li-Ping, Liang Bing-Qing, Cai Jian-Ping, Hu Guo-Xin

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) is an important member of the cytochrome P450 enzyme superfamily. We recently identified 22 novel variants in the Chinese population using PCR and bidirectional sequencing methods. The aim of this study is to characterize the enzymatic activity of these variants and their effects on the metabolism of the antimuscarinic drug tolterodine in vitro. A baculovirus-mediated expression...

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PMID: 28087463
DOI: 10.1016/j.cbi.2017.01.003

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