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Article

Comparison of cytochrome P450 2D6 and variants in terms of drug oxidation rates and substrate inhibition.

Current drug metabolism - 1 Jun 2011

Niwa Toshiro, Murayama Norie, Yamazaki Hiroshi

Abstract excerpt

This review focuses on identification of the important active site residues of CYP2D6 in terms of CYP2D6 polymorphism. A meta-analysis was performed on the reported literature regarding (1) values of the Michaelis-Menten constant (K(m)), maximal velocity (V(max)), and intrinsic clearance (V(max)/K(m)) for 41 metabolic reactions of 31 substrates mediated by human cytochrome P450 2D6 and its variants and mutants...

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Identifiers

PMID: 21453270
DOI: 10.2174/138920011795495286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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