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Article

Functional characterization of 22 novel CYP2D6 variants for the metabolism of Tamoxifen.

The Journal of pharmacy and pharmacology - 1 Jun 2016

Hu Xiao-Xia, Zhou Quan, Lan Tian, Huang Xiang-Xin, Liang Bing-Qing, Dai Da-Peng, Cai Jian-Ping, Hu Guo-Xin

Abstract excerpt

OBJECTIVES: This study aimed to assess the catalytic characteristics of 24 CYP2D6 allelic isoforms found in Chinese Han population on the metabolism of tamoxifen in vitro. METHODS: Recombinant CYP2D6 microsomes of distinguished genotypes were used to characterize the corresponding enzyme activity towards tamoxifen. About 5-2500 μm tamoxifen was incubated for 30 min at 37 °C. Using high-performance liquid...

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Identifiers

PMID: 27109434
DOI: 10.1111/jphp.12556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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