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Article

In vitro assessment of 24 CYP2D6 allelic isoforms on the metabolism of methadone.

Drug testing and analysis - 1 Feb 2017

Su Ying, Zhan Yun-Yun, Wang Ben-Fu, Wang Si-Cong, Dai Da-Peng, Hu Guo-Xin, Lin Han, Lian Qing-Quan, Cai Jian-Ping

Abstract excerpt

CYP2D6 is an important member of the cytochrome P450 (CYP450) enzyme super family, with at least 100 CYP2D6 alleles being previously identified. Genetic polymorphisms of CYP2D6 significantly influence the efficacy and safety of some drugs, which might cause adverse effects and therapeutic failure. The aim of this study was to clarify the catalytic activities of 24 CYP2D6 alleles on the oxidative in vitro...

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Identifiers

PMID: 26968424
DOI: 10.1002/dta.1959

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