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Article

Effect of CYP2D6 variants on venlafaxine metabolism in vitro.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Jan 2016

Zhan Yun-Yun, Liang Bing-Qing, Wang Hao, Wang Zhen-He, Weng Qing-Hua, Dai Da-Peng, Cai Jian-Ping, Hu Guo-Xin

Abstract excerpt

1. CYP2D6 is an important member of the cytochrome P450 (CYP450) enzyme superfamily, we recently identified 22 CYP2D6 alleles in the Han Chinese population. The aim of this study was to assess the catalytic activities of these allelic isoforms and their effects on the metabolism of venlafaxine in vitro. 2. The wild-type and 24 CYP2D6 variants were expressed in insect cells, and each variant was characterized...

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Identifiers

PMID: 26406933
DOI: 10.3109/00498254.2015.1089364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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