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Article

Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer.

Oncotarget - 27 Sept 2016

Ahn Jinwoo, Kim Kwang Hyun, Park Sanghui, Ahn Young-Ho, Kim Ha Young, Yoon Hana, Lee Ji Hyun, Bang Duhee, Lee Dong Hyeon

Abstract excerpt

UTX is a histone demethylase gene located on the X chromosome and is a frequently mutated gene in urothelial bladder cancer (UBC). UTY is a paralog of UTX located on the Y chromosome. We performed target capture sequencing on 128 genes in 40 non-metastatic UBC patients. UTX was the most frequently mutated gene (30%, 12/40). Of the genetic alterations identified, 75% were truncating mutations. UTY copy number loss...

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Identifiers

PMID: 27533081
DOI: 10.18632/oncotarget.11207
PMCID: PMC5325361

Genes

UBC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer.PMID 27533081Read ↗

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