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Genetic Studies Highlight the Role of TET2 and INO80 in DNA Damage Response and Kidney Disease Pathogenesis

2024-02-07

Abstract excerpt

Genome-wide association studies (GWAS) have identified over 800 loci associated with kidney function, yet the specific genes, variants, and pathways involved remain elusive. By integrating kidney function GWAS, human kidney expression and methylation quantitative trait analyses, we identified Ten-Eleven Translocation (TET) DNA demethylase 2: TET2 as a novel kidney disease risk gene. Utilizing single-cell chromatin...

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Literature Corpus work
943da8d9-ab44-590c-ab38-f30a9b349409
DOI
10.1101/2024.02.02.578718
Open publication

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Genetic Studies Highlight the Role of TET2 and INO80 in DNA Damage Response and Kidney Disease PathogenesisDOI 10.1101/2024.02.02.578718
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