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Article

Loss of UTX/KDM6A and the activation of FGFR3 converge to regulate differentiation gene-expression programs in bladder cancer.

Proceedings of the National Academy of Sciences of the United States of America - 13 Oct 2020

Barrows Douglas, Feng Lijuan, Carroll Thomas S, Allis C David

Abstract excerpt

Bladder cancer prognosis is closely linked to the underlying differentiation state of the tumor, ranging from the less aggressive and most-differentiated luminal tumors to the more aggressive and least-differentiated basal tumors. Sequencing of bladder cancer has revealed that loss-of-function mutations in chromatin regulators and mutations that activate receptor tyrosine kinase (RTK) signaling frequently occur...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Share to Receptor, Fibroblast Growth Factor, Type 3

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Source

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Identifiers

PMID: 32989154
DOI: 10.1073/pnas.2008017117
PMCID: PMC7568298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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