Article
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.
Nature genetics - 1 May 2009
van Haaften Gijs, Dalgliesh Gillian L, Davies Helen, Chen Lina, Bignell Graham, Greenman Chris, Edkins Sarah, Hardy Claire, O'Meara Sarah, Teague Jon, Butler Adam, Hinton Jonathan, Latimer Calli, Andrews Jenny, Barthorpe Syd, Beare Dave, Buck Gemma, Campbell Peter J, Cole Jennifer, Forbes Simon, Jia Mingming, Jones David, Kok Chai Yin, Leroy Catherine, Lin Meng-Lay, McBride David J, Maddison Mark, Maquire Simon, McLay Kirsten, Menzies Andrew, Mironenko Tatiana, Mulderrig Lee, Mudie Laura, Pleasance Erin, Shepherd Rebecca, Smith Raffaella, Stebbings Lucy, Stephens Philip, Tang Gurpreet, Tarpey Patrick S, Turner Rachel, Turrell Kelly, Varian Jennifer, West Sofie, Widaa Sara, Wray Paul, Collins V Peter, Ichimura Koichi, Law Simon, Wong John, Yuen Siu Tsan, Leung Suet Yi, Tonon Giovanni, DePinho Ronald A, Tai Yu-Tzu, Anderson Kenneth C, Kahnoski Richard J, Massie Aaron, Khoo Sok Kean, Teh Bin Tean, Stratton Michael R, Futreal P Andrew
Abstract excerpt
Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in...
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