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Article

Inhibition of long non-coding RNA UCA1 by CRISPR/Cas9 attenuated malignant phenotypes of bladder cancer.

Oncotarget - 7 Feb 2017

Zhen Shuai, Hua Ling, Liu Yun-Hui, Sun Xiao-Min, Jiang Meng-Meng, Chen Wei, Zhao Le, Li Xu

Abstract excerpt

CRISPR/Cas9 is a novel and effective genome editing technique, but its application is not widely expanded to manipulate long non-coding RNA (lncRNA) expression. The lncRNA urothelial carcinoma-associated 1 (UCA1) is upregulated in bladder cancer and promotes the progression of bladder cancer. Here, we design gRNAs specific to UCA1 and construct CRISPR/Cas9 systems targeting UCA1. Single CRISPR/Cas9-UCA1 can...

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Source

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Identifiers

PMID: 28038452
DOI: 10.18632/oncotarget.14176
PMCID: PMC5354759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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