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Article

Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression

31 Mar 2023

Abstract excerpt

Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX), also known as lysine (K)-specific demethylase 6A (KDM6A), functions as a tumor suppressor gene or oncogene depending on the tumor type and context. However, its tumor-suppressive mechanisms remain largely unknown. Here, we investigated the clinical significance and biological effects of UTX expression in pancreatic ductal adenocarcinoma...

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Identifiers

PMID: 37692474
DOI: 10.1016/j.gendis.2023.01.019

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